Our research group at the University of Sydney’s Save Sight Institute combines cutting-edge computational methods with clinical expertise to advance our understanding of multiple sclerosis progression. Led by our multidisciplinary team of researchers, we’ve developed innovative approaches to track and analyze chronic lesion evolution in MS using advanced MRI techniques.
Our work has revealed groundbreaking insights into how MS lesions expand over time and contribute to disease progression. Using custom-developed software pipelines and artificial intelligence, we’ve demonstrated that chronic lesion expansion follows distinct patterns and plays a crucial role in disability accumulation. These findings have attracted international attention and sparked collaborations with research centers across Europe and pharmaceutical partners including Novartis, Merck, and REKOVER.
Professor Alexander Klistorner
Lead Investigator
Professor Klistorner leads our neuroimaging and electrophysiology research at the University of Sydney, bringing over 20 years of dedicated expertise in multiple sclerosis research. His pioneering work focuses on understanding demyelination, neurodegeneration, and chronic inflammation in MS through innovative imaging and electrophysiological techniques.
As a founding member of the IMSVISUAL consortium, an international group studying visual systems in MS, Prof Klistorner has shaped the field’s research directions and clinical trial methodologies. His contributions include developing new methodologies for analyzing multifocal visual evoked potentials, leading to 7 patents and establishing new standards in the field. With over 150 publications and an h-index of 53, his research has significantly advanced our understanding of MS pathology.
Prof Klistorner has secured over $7 million in research funding from prestigious organizations including NHMRC and the National MS Society (USA). His leadership extends to mentoring the next generation of researchers, having supervised 10 PhD students to completion, with four now leading their own research groups as Associate Professors. He continues to chair MS research group meetings at the Brain Mind Center while supervising multiple clinical visual electrophysiology labs.
Samuel Klistorner
Lead Software Engineer and Research Scientist
Samuel leads the development of our computational methodologies and MRI analysis pipelines, bringing together expertise in software engineering and neurological research. His pioneering work in chronic lesion tracking has established new ways to monitor MS progression. Recently completing his PhD on “Advancements in the Understanding of Chronic Lesion Expansion and Smouldering Inflammation in Multiple Sclerosis,” his research has led to 10 first-author publications in leading journals.
Samuel’s innovations include developing AI-driven applications for disease monitoring and creating novel techniques for analyzing brain lesion evolution. His work spans international collaborations with research centers in Spain, the UK, Finland, Germany, and Norway. He regularly presents at major conferences including ECTRIMS and MS Research Australia, advancing our understanding of MS progression mechanisms.
MS Lesion Analytics 