Dear Participants of MAD-MS Study,

Your participation in the MAD-MS study has led to groundbreaking discoveries that are reshaping our understanding of multiple sclerosis. Together, we’ve revealed how chronic MS lesions expand due to persistent inflammation, discovered the critical role of the choroid plexus as a new biomarker for disease progression, and provided the first human evidence linking chronic demyelination to nerve fiber loss. These findings, published in 36 papers across leading medical journals including Brain and Lancet Neurology, are already influencing clinical trials and treatment approaches worldwide. The measurement tools we developed are now being used globally to test new therapies and monitor disease progression more effectively.

Thank you for your participation in the MAD-MS study. Your involvement has been instrumental in advancing our understanding of MS and the role of chronic (smouldering) inflammation in disease progression. We are incredibly grateful for your contribution.

For detailed study outcomes, click here…

Building on the insights gained from MAD-MS, we have designed a clinical trial called COMPASS-MS. This retrospective study aims to evaluate the impact of current disease-modifying therapies (DMTs) on smouldering inflammation and disease progression in MS. By leveraging existing data from multiple sites, COMPASS-MS will generate actionable insights within 12–18 months, significantly faster than traditional prospective trials.

The study will provide a comprehensive assessment of which therapies are most effective in addressing progressive aspects of MS. These findings have the potential to transform lives by identifying treatments that can slow or prevent the accumulation of disability caused by chronic inflammation.

While we are currently working to secure funding for COMPASS-MS, our team remains fully committed to advancing this critical research.

We sincerely appreciate your continued support and interest in our research. If you would like to stay updated on our progress or have any questions about the study, please feel free to reach out.

We would like to invite you to join our MS Consumer Panel for future research initiatives. If you’d like to contribute your valuable insights and experiences to upcoming studies, please click here to register your interest via our contact page.

Best regards,

Alexander Klistorner